Alessia Del Pasqua1, Silvina Barcudi1, Benedetta Leonardi1, Domenico Clemente2, Mauro Colajacomo2, Stephen P Sanders3
1 Medical Surgical Department of Pediatric Cardiology, Ospedale Pediatrico Bambino Gesł, Rome, Italy
2 Department of Diagnostic Imaging, Ospedale Pediatrico Bambino Gesł, Rome, Italy
3 Cardiac Registry, Department of Cardiology, Children's Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Background : Contrast MRA (C-MRA) is the standard for quantitative analysis of thoracic vessels. We evaluated a noncontrast MRA (NC-MRA) sequence (3-D EKG and navigator-gated SSFP) for quantitative evaluation of the thoracic aorta and branch pulmonary arteries in young patients with congenital heart disease.
Objective : To compare contrast and noncontrast magnetic resonance angiography for quantitative analysis of thoracic arteries in young patients with congenital heart defects.
Methods : Measurements of thoracic aorta and branch pulmonary arteries were obtained from C-MRA and NC-MRA images in 51 patients, ages 2-35 years. Vessel diameters were compared using correlation and Bland-Altman analysis. Interobserver variability was assessed using percent variation.
Results : C-MRA and NC-MRA measurements were highly correlated (r = 0.91-0.98) except for the right pulmonary artery (r = 0.74, 0.78). Agreement of measurements was excellent (mean difference -0.07 to -0.53 mm; mean % difference -1.8 to -4.9%) except for the right pulmonary artery which was less good (mean difference 0.73, -1.38 mm; -3, -10%). Interobserver variability ranged from 5% to 8% for aortic and from 10% to 16% for pulmonary artery measures. The worse agreement and greater variability of the pulmonary artery measures appears due to difficulty standardizing the measurements in patients with abnormal and irregular vessels.
Conclusion : These data indicate that C-MRA and NC-MRA measures are comparable and could be used interchangeably, avoiding administration of contrast in selected patients.
Stephen P Sanders
Cardiac Registry, Department of Cardiology,Children's Hospital Boston, 300 Longwood Ave., Boston, MA 02115
Source of Support: None, Conflict of Interest: None
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