Himesh V Vyas1, Benjamin W Eidem1, Frank Cetta1, Ganesh Acharya2, James Huhta2, David Roberson3, Bettina Cuneo4
1 Department of Pediatrics, Division of Pediatric Cardiology, Mayo Clinic College of Medicine, Rochester, MN, USA
2 Department of Pediatrics and Obstetrics/Gynecology, All Children's Hospital, University of South Florida, St. Petersburg, FL, USA
3 The Heart Institute for Children, Hope Children's Hospital, Oak Lawn, USA
4 The Heart Institute for Children, Hope Children's Hospital, Oak Lawn; Department of Pediatrics and Obstetrics, Rush Medical College, Chicago, IL, USA
Background : Tissue Doppler Imaging (TDI) is a sensitive index of myocardial function. Its role in the fetus has not been extensively evaluated.
Objective: To compare myocardial tissue Doppler velocities in fetuses with hypoplastic left heart syndrome (HLHS) to those of normal fetuses (matched for gestational age.)
Methods: Cross-sectional retrospective study conducted at 2 large perinatal centers (2003-2007). Fetuses with HLHS ( n = 13) were compared with normal fetuses ( n = 207) in 5 gestational age groups. TDI data included peak systolic (s'), peak early (e'), and late diastolic velocities (a'). Linear regression was used to compare TDI parameters in fetuses with HLHS to normal fetuses matched for gestational age.
Results: Fetuses with HLHS had significantly reduced lateral tricuspid annular e' as compared to normal fetuses. Both normal fetuses and those with HLHS had linear increase in TDI velocities with advancing gestational age.
Conclusions: TDI velocities are abnormal in fetuses with HLHS. TDI can be useful in serial follow-up of cardiac function in fetuses with HLHS.
Himesh V Vyas
University of Arkansas for Medical Sciences and Arkansas Children's Hospital, 1 Children's Way, Slot 512 3, Little Rock, AR 72202
Source of Support: None, Conflict of Interest: None
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