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Table of Contents   
INVITED COMMENT  
Year : 2014  |  Volume : 7  |  Issue : 1  |  Page : 25-28
Post cardiac surgery junctional ectopic tachycardia: A 'Hit and Run' tachyarrhythmia as yet unchecked


Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India

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Date of Web Publication5-Feb-2014
 

How to cite this article:
Tharakan JA, Sukulal K. Post cardiac surgery junctional ectopic tachycardia: A 'Hit and Run' tachyarrhythmia as yet unchecked. Ann Pediatr Card 2014;7:25-8

How to cite this URL:
Tharakan JA, Sukulal K. Post cardiac surgery junctional ectopic tachycardia: A 'Hit and Run' tachyarrhythmia as yet unchecked. Ann Pediatr Card [serial online] 2014 [cited 2019 Sep 23];7:25-8. Available from: http://www.annalspc.com/text.asp?2014/7/1/25/126545


Junctional ectopic tachycardia (JET) presents in two scenarios: The rarer idiopathic and incessant form seen early in infancy with a structurally normal heart and the more common self-limiting variety limited to the early postoperative period after surgical repair of congenital heart disease.

Postoperative arrhythmias after open-heart surgery for congenital heart disease contribute significantly to both morbidity and mortality. Arrhythmias often well tolerated in a normal heart can be a major cause of morbidity and mortality after cardiac surgery for congenital heart disease. [1] JET is the most frequent hemodynamically significant tachycardia in the postoperative setting and usually occurs within the first 24 hours after operation. [2],[3],[4] Hemodynamic instability results from loss of atrioventricular synchrony and extreme tachycardia. [5]

Diagnosis of JET generally requires a heart rate greater than 170 beats per minute with QRS morphology similar to the sinus rhythm QRS complex, atrioventricular dissociation, and ventricular rate faster than the atrial rate. [6] JET can occur at a lower rate in adult population with increased vagal tone and slower atrioventricular (AV) conduction as compared to children. It can also present with 1:1 retrograde ventriculo-atrial conduction. In patients with postoperative bundle branch block, JET can manifest as wide QRS tachycardia with atrioventricular dissociation or 1:1 retrograde ventriculo-atrial conduction. In this scenario, the P waves may fall within the QRS or ST-T segment. At fast rates, sinus tachycardia and supraventricular arrhythmias can pose a diagnostic challenge. P waves can be the clue in such situations that can be identified with oesophageal leads or Lewis leads or the atrial pacing wires.

The precise mechanism of JET is not known, but it is believed to result from mechanical trauma to the proximal conduction tissue related to suture placement or indirect stretch injury with resultant edema which can occur during resection of muscle bundles, correction of right ventricular outflow tract and correction of ventricular septal defects. [7] Paradoxically, JET also occurs in patients in whom surgery does not involve areas around the atrioventricular node. Furthermore cardiopulmonary bypass (CPB) with ischemia-reperfusion and the related cellular biochemical effects as well as medical interventions such as electrolyte shifts and catecholamine administration may affect the stability of the cellular membrane and result in an increased myocardial irritability and automaticity. [8]

Risk factors associated with JET include younger patient age, duration of CPB and aortic cross-clamp time (ACC), electrolyte disturbances, use of inotropes and type of surgery. [6],[9] Several studies have elucidated the risk factors associated with JET. [Table 1] Although higher dose of inotropic agents have been accepted in all major studies as a significant risk factor, the role of surgery involving peri-nodal areas is still debated. Moak et al., [11] in their recent study had categorically refuted mechanical injury to the AV node area as a strong risk factor for postoperative JET.
Table 1: Incidence and risk factors for postoperative JET


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The prospective study on postoperative JET by Abelaziz et al., [12] published in this issue of the Annals, has analyzed 194 patients after their cardiac surgery under CPB. They have divided their cohort into 3 groups - one with postoperative JET, one with other postoperative arrhythmias and finally those with no arrhythmias. This division further helps to highlight the risk factors that may be more specific for JET with respect to other postoperative arrhythmias. They have used the conventional measures to diagnose JET, but have still highlighted the importance of atrial leads, Lewis leads and esophageal leads in confirming their diagnosis.

The staged protocol for management of JET has some scientific basis, even though the use of bolus dose of magnesium sulphate is questioned by several studies. [2],[4],[9]

The number of patients who developed JET in the postoperative period (27%) in this study sample is significantly high as compared to previous studies. The reasons that the authors have extrapolated for this high number include the higher number of surgeries being done in their centre, which have an inherently high risk of developing postoperative JET like Tetralogy of Fallot (TOF), atrioventricular canal defect, Senning operation and also the later age of surgery for congenital heart disease (CHD) in their hospital. These explanations may be acceptable but even then the number of postoperative JET incidence for each respective surgery is still higher as compared to previous data. [9],[13] It has also been shown previously that incidence of JET decreases with higher age and weight of the baby and so the latter explanation also cannot hold good. [9],[14]

It is interesting to note that risk factors when compared between the 3 groups mentioned above have shown that CPB, aortic cross clamp time and postoperative use of inotropes were significantly higher in postoperative JET patients but there was no significant difference in these parameters between non-JET arrhythmia group and no arrhythmia group. This clearly highlights the importance of perioperative factors being a major determinant of JET and anatomical factors being a minor determinant only. The structural abnormalities and their corresponding electrophysiological changes may be stronger determinants of non-JET arrhythmias.

In this study, patients experienced JET in the immediate postoperative period (range, 1 to 24 hours post bypass; median, 6.8 hours). Previous studies have documented JET to occur in early postoperative period but not confined to first 24 hours. [11]

In the present study, JET successfully resolved in 86.5% (n = 47) of patients, with 57% (n = 30) responding to conventional measures (cooling, magnesium sulphate, sedation and minimizing catecholamines) and the remaining 43% (n = 23) were controlled by IV amiodarone infusion in addition to conventional measures. In Hoffman's study, 39.4% required other measures in addition to conventional treatment for management. [9]

The statistical difference between the role of milrinone and other inotropes in causing JET is not readily explained. Although other inotropes act directly on the beta-receptors, milrinone acts only at the second messenger level but the final mechanism of action at the cellular level is common to both. In Hoffman's study, milrinone had an equally significant role in JET as other inotropes. [9]

Post-surgical JET has a mortality as high as 14%. [4] So preventive strategies should be given adequate importance in the early postoperative period. Prevention of hyperthermia and minimal inotropic usage are important. The administration of magnesium either as a bolus at the completion of the rewarming phase of CPB or as a continuous intravenous infusion after discontinuance from CPB has been demonstrated to lower the incidence of postoperative JET and other cardiac arrhythmias. [15] Mahmoud et al., demonstrated a lower incidence of PO JET (38% vs. 21%) when propranolol was initiated preoperatively for TOF patients. [16]

The management of JET patients requires a staged therapeutic approach beginning with conventional measures that include active avoidance of hyperthermia, optimal sedation and pain control and minimizing exogenous catecholamines. In one of the earlier publications evaluating the effectiveness of a staged protocol, Walsh et al., [6] found that conventional measures could control JET in 24% of patients. Based on available data and institutional experience, they refined their original protocol by avoiding ineffective drugs like digoxin, verapamil, propranolol and phenytoin. These measures significantly reduced the time to JET control. In the case of non-responders or patients with hemodynamic instability, they have followed a sequential order of atrial pacing, induction of hypothermia with posterior cooling blankets and finally a combination of hypothermia and antiarrhythmic drugs like amiodarone and procainamide. In 70 of their 71 patients, JET was managed successfully with 63 patients responding within 2 hours.

This order has undergone considerable changes overtime with intravenous amiodarone being preferred by several centres now as 1 st or 2 nd line option. [4],[17] Active surface cooling using cooling blankets and cold saline infusions is effective in terminating resistant JET. [17],[18] In the early postoperative period, surface cooling may be preferred prior to amiodarone infusion. In patients with JET presenting in the late postoperative period, the use of surface cooling prior to amiodarone infusion is still debated. Atrial pacing at fast rates for AV sequential pacing is another option for resistant JET. [9] Dexmedetomidine may be useful in prevention and treatment of perioperative JET. [19],[20] Other antiarrhythmics like intravenous flecainide, [21] procainamide [22] and nifekalant [23] have been reported to be useful for controlling JET resistant to other measures. Ablation as a final resort after failed medical management in hemodynamically unstable patients have also been reported. [24],[25]

The incidence of JET has gradually declined over the years with improved surgical techniques and preventive measures like minimizing inotropic usage and avoiding hyperthermia in the postoperative period. But JET continues to contribute significantly to postoperative morbidity. Management of JET with general supportive measures, active surface cooling and antiarrhythmics like amiodarone has reined this postoperative hazard to a great extent.

 
   References Top

1.Herzog L, Lynch C. Arrhythmias accompanying cardiac surgery. In: Lynch C, editor. Clinical Cardiac Electrophysiology. 3 rd ed. Philadelphia: JB Lippincott; 1994. p. 231-58.  Back to cited text no. 1
    
2.Batra AS, Chun DS, Johnson TR, Maldonado EM, Kashyap BA, Maiers J, et al. A prospective analysis of the incidence and risk factors associated with junctional ectopic tachycardia following surgery for congenital heart disease. Pediatr Cardiol 2006;27:51-5.  Back to cited text no. 2
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3.Delaney JW, Moltedo JM, Dziura JD, Kopf GS, Snyder CS. Early postoperative arrhythmias after pediatric cardiac surgery. J Thorac Cardiovasc Surg 2006;131:1296-300.  Back to cited text no. 3
[PUBMED]    
4.Mildh L, Hiippala A, Rautiainen P, Pettila V, Sairanen H, Happonen JM. Junctional ectopic tachycardia after surgery for congenital heart disease: Incidence, risk factors and outcome. Eur J Cardiothorac Surg 2011;39:75-80.  Back to cited text no. 4
    
5.Dodge-Khatami A, Miller OI, Anderson RH, Gil-Jaurena JM, Goldman AP, de Leval MR. Impact of junctional ectopic tachycardia on postoperative morbidity following repair of congenital heart defects. Eur J Cardiothorac Surg 2002;21:255-9.  Back to cited text no. 5
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6.Walsh EP, Saul JP, Sholler GF, Triedman JK, Jonas RA, Mayer JE, et al. Evaluation of a staged treatment protocol for rapid automatic junctional tachycardia after operation for congenital heart disease. J Am Coll Cardiol 1997;29:1046-53.  Back to cited text no. 6
[PUBMED]    
7.Dodge-Khatami A, Miller OI, Anderson RH, Goldman AP, Gil-Jaurena JM, Elliott MJ, et al. Surgical substrates of postoperative junctional ectopic tachycardia in congenital heart defects. J Thorac Cardiovasc Surg 2002;123:624-30.  Back to cited text no. 7
    
8.Pfammatter JP, Paul T, Ziemer G, Kallfelz HC. Successful management of junctional tachycardia by hypothermia after cardiac operations in infants. Ann Thorac Surg 1995;60:556-60.  Back to cited text no. 8
[PUBMED]    
9.Hoffman TM, Bush DM, Wernowsky G, Cohen MI, Wieand TS, Gaynor JW, et al. Postoperative junctional ectopic tachycardia in children: Incidence, risk factors and treatment. Ann Thorac Surg 2002;74:1607-11.  Back to cited text no. 9
    
10.Grosse-Wortmann L, Kreitz S, Kreitz RG, Vasquez-Jiminez JF, Messmer BJ, von Bernuth G, et al. Prevalence of and risk factors for perioperative arrhythmias in neonates and children after cardiopulmonary bypass: Continuous holter monitoring before and for three days after surgery. J Cardiothoracic Surg 2010;5:85.  Back to cited text no. 10
    
11.Moak JP, Arias P, Kaltman JR, Cheng Y, McCarter R, Hanumanthaiah S, et al. Postoperative junctional ectopic tachycardia: Risk factors for occurrence in the modern surgical era. Pacing Clin Electrophysiol 2013;36:1156-68.  Back to cited text no. 11
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12.Abelaziz O, Deraz S, Anticipation and management of junctional ectopic tachycardia in postoperative cardiac surgery: Single center experience with high incidence. Ann Pediatr Card 2014;7:19-24.  Back to cited text no. 12
    
13.Rekawek J, Kansy A, Miszczaj-Knecht M, Manowska M, Bieganowska K, Brzezinska-Paszke M, et al. Risk factors for cardiac arrhythmias in children with congenital heart disease after surgical intervention in the early postoperative period. J Thorac Cardiovasc Surg 2007;133:900-4.  Back to cited text no. 13
    
14.Valsangiacomo E, Schmid ER, Schupbach RW, Schmidlin D, Molinari L, Waldvogel K, et al. Early postoperative arrhythmias after cardiac operation in children. Ann Thorac Surg 2002;74:792-6.  Back to cited text no. 14
    
15.Manrique AM, Arroyo M, Lin Y, El Khoudary SR, Colvin E, Lichtenstein S, et al. Magnesium supplementation during cardiopulmonary bypass to prevent junctional ectopic tachycardia after pediatric surgery: A randomized controlled study. J Thorac Cardiovasc Surg 2010;139:162-169.e2.  Back to cited text no. 15
    
16.Mahmoud AB, Tantawy AE, Kouatli AA, Baslaim GM. Propranolol: A new indication for an old drug in preventing postoperative junctional ectopic tachycardia after surgical repair of tetralogy of Fallot. Interact Cardiovasc Thorac Surg 2008;7:184-7.  Back to cited text no. 16
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17.Kovacikova L, Hakacova N, Dobos D, Skrak P, Zahorec M. Amiodarone as a first-line therapy for postoperative junctional ectopic tachycardia. Ann Thorac Surg 2009;88;616-22.  Back to cited text no. 17
    
18.Kelly BP, Gajarski RJ, Ohye RG, Charpie JR. Intravenous induction of therapeutic hypothermia in the management of junctional ectopic tachycardia: A pilot study. Pediatr Cardiol 2010;31:11-7.  Back to cited text no. 18
[PUBMED]    
19.Chrysostomou C, Beerman L, Shiderly D, Berry D, Morell VO, Munoz R. Dexmedetomidine: A novel drug for the treatment of atrial and junctional tachyarrhythmias during the perioperative period for congenital cardiac surgery: A preliminary study. Anesth Analg 2008;107:1514-22.  Back to cited text no. 19
[PUBMED]    
20.LeRiger M, Naguib A, Gallantowicz M, Tobias JD. Dexmedetomidine controls junctional ectopic tachycardia during Tetralogy of Fallot repair in an infant. Ann Card Anaesth 2012;15:224-8.  Back to cited text no. 20
[PUBMED]  Medknow Journal  
21.Bronzetti G, Formigari R, Giardini A, Frascaroli G, Gargiulo G, Picchio FM. Intravenous flecainide for the treatment of junctional ectopic tachycardia after surgery for congenital heart disease. Ann Thorac Surg 2003;76:148-51.  Back to cited text no. 21
    
22.Mandapati R, Byrum CJ, Kavey RE, Smith FC, Kveselis DA, Hannan WP, et al. Procainamide for rate control of postsurgical junctional tachycardia. Pediatr Cardiol 2000;21:123-8.  Back to cited text no. 22
[PUBMED]    
23.Sasaki T, Nemoto S, Ozawa H, Katsumata T, Ozaki N, Okumura K, et al. Successful administration of nifekalant hydrochloride for postoperative junctional ectopic tachycardia in congenital cardiac surgery. Kyobu Geka 2007;60:1022-6.  Back to cited text no. 23
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24.Tsoutsinos AJ, Papagiannis J, Chatzis AC, Sarris GE. Surgical cryoablation for life threatening postoperative junctional tachycardia. Ann Thorac Surg 2007;84:286-8.  Back to cited text no. 24
[PUBMED]    
25.Braunstein PW Jr, Sade RM, Gillette PC. Life-threatening postoperative junctional ectopic tachycardia. Ann Thorac Surg 1992;53:726-8.  Back to cited text no. 25
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Correspondence Address:
Jaganmohan A Tharakan
Professor and Director, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram - 695 011, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-2069.126545

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