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Redux valvular surgery with coronary artery bypass graft in familial hypercholesterolemia


Department of Cardiovascular and Thoracic, Rabta Hospital, Medical University of Tunis, Tunis, Tunisia

Correspondence Address:
Ziadi Jalel
Cardiovascular and Thoracic Department, Rabta Hospital, Jebbari Street, 1001 Tunis
Tunisia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-2069.126563

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Year : 2014  |  Volume : 7  |  Issue : 1  |  Page : 61-63

 

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Familial hypercholesterolemia (FH) is a dominantly inherited disorder caused by mutation at the locus for the low-density lipoprotein (LDL) receptor and is frequently associated with premature coronary artery disease and aortic valve involvement. The surgical treatment of these complications is accompanied by a high degree of risk, even in skillful hands. An intensive cholesterol-lowering therapy and LDL aphaeresis in association with surgery may be useful. The case of a 12-year-old girl, with a medical history of familial hypercholesterolemia is reported here, operated two years previously for valvular aortic stenosis; Ross intervention was done. She was readmitted for acute coronary syndrome. Three coronary artery bypass grafting was performed with saphenous veins with positive results.






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Department of Cardiovascular and Thoracic, Rabta Hospital, Medical University of Tunis, Tunis, Tunisia

Correspondence Address:
Ziadi Jalel
Cardiovascular and Thoracic Department, Rabta Hospital, Jebbari Street, 1001 Tunis
Tunisia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-2069.126563

Rights and Permissions

Familial hypercholesterolemia (FH) is a dominantly inherited disorder caused by mutation at the locus for the low-density lipoprotein (LDL) receptor and is frequently associated with premature coronary artery disease and aortic valve involvement. The surgical treatment of these complications is accompanied by a high degree of risk, even in skillful hands. An intensive cholesterol-lowering therapy and LDL aphaeresis in association with surgery may be useful. The case of a 12-year-old girl, with a medical history of familial hypercholesterolemia is reported here, operated two years previously for valvular aortic stenosis; Ross intervention was done. She was readmitted for acute coronary syndrome. Three coronary artery bypass grafting was performed with saphenous veins with positive results.






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