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Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes


1 Research Centers in Nutrition and Health, Madrid, Spain
2 Department of Medicine, Universidad Complutense de Madrid, Madrid, Spain
3 Hospital El Escorial, San Lorenzo de El Escorial, Madrid, Spain

Correspondence Address:
Dr. Ismael San Mauro Martín
Research Centers in Nutrition and Health, 43 Paseo de la Habana Street, 28036, Madrid
Spain
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/apc.APC_86_18

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Year : 2019  |  Volume : 12  |  Issue : 2  |  Page : 83-89

 

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Background: Dyslipidemias have increased during the last decades in children. Aim: The objective of this study was to analyze the influence of different polymorphisms in plasma triglyceride levels of children following a dietary treatment with plant sterols. Design: A randomized, double-blind, crossover, controlled clinical trial was carried out in 26 children (16 women). Materials and Methods: Commercial milk, with 2.24 g sterols, was ingested daily during 3 weeks , and the same amount of skimmed milk without sterols, during the 3 week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed. Results: Apolipoprotein A5 Ser19Trp (P = 0.002), peroxisome proliferator-activated receptor-alpha L162V (P = 0.003), APOE APOE2/3/4 (P = 0.012), and APOE APOE2,3,4 (P = 0.025) show statistically significant differences between their haplotypes in plasma triglyceride levels. Other genes did not show statistically significant differences. Conclusions: Further studies are needed to establish which genotype combinations would be the most protective against hypertriglyceridemia.






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 ORIGINAL ARTICLE
 




1 Research Centers in Nutrition and Health, Madrid, Spain
2 Department of Medicine, Universidad Complutense de Madrid, Madrid, Spain
3 Hospital El Escorial, San Lorenzo de El Escorial, Madrid, Spain

Correspondence Address:
Dr. Ismael San Mauro Martín
Research Centers in Nutrition and Health, 43 Paseo de la Habana Street, 28036, Madrid
Spain
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/apc.APC_86_18

Rights and Permissions

Background: Dyslipidemias have increased during the last decades in children. Aim: The objective of this study was to analyze the influence of different polymorphisms in plasma triglyceride levels of children following a dietary treatment with plant sterols. Design: A randomized, double-blind, crossover, controlled clinical trial was carried out in 26 children (16 women). Materials and Methods: Commercial milk, with 2.24 g sterols, was ingested daily during 3 weeks , and the same amount of skimmed milk without sterols, during the 3 week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed. Results: Apolipoprotein A5 Ser19Trp (P = 0.002), peroxisome proliferator-activated receptor-alpha L162V (P = 0.003), APOE APOE2/3/4 (P = 0.012), and APOE APOE2,3,4 (P = 0.025) show statistically significant differences between their haplotypes in plasma triglyceride levels. Other genes did not show statistically significant differences. Conclusions: Further studies are needed to establish which genotype combinations would be the most protective against hypertriglyceridemia.






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