Year : 2012  |  Volume : 5  |  Issue : 1  |  Page : 21--26

Impact of congenital heart disease on brain development in newborn infants


Moustafa M Abdel Raheem, Walid A Mohamed 
 Department of Pediatrics, Faculty of Medicine, Menia University, Minia, Egypt, Department of Pediatrics, College of Medicine, King Khalid University, Abha, Saudi Arabia

Correspondence Address:
Moustafa M Abdel Raheem
Assistant Professor of Paediatrics College of Medicine, King Khalid University, Abha, P.O. Box-641,Asser Region
Saudi Arabia

Objective: To assess brain development and brain injury in neonates with cyanotic and acyanotic congenital heart disease (CHD). Methods: The study included 52 term infants with CHD who were divided into two groups: Cyanotic (n=21) and acyanotic (n=31). Fifteen healthy neonates of matched age and sex were enrolled in the study as controls. Three-dimensional proton magnetic resonance spectroscopic imaging and diffusion tensor imaging were used to assess brain development and injury. We calculated the ratio of N-acetylaspartate (NAA) to choline (which increases with maturation), average diffusivity (which decreases with maturation), fractional anisotropy of white matter (which increases with maturation), and the ratio of lactate to choline (which increases with brain injury). Results: As compared with control neonates, those with CHD had significant decrease in NAA/choline ratio (P<0.001), significant increase in lactate/choline ratio (P<0.0001), significant increase in average diffusivity (P<0.0001), and significant decrease of white matter fractional anisotropy (P<0.001). Neonates with cyanotic CHD had significant less brain development and more brain injury than those with acyanotic CHD (P<0.05). Conclusions: Newborn infants with cyanotic and acyanotic CHD are at high risk of brain injury and impaired brain maturity.


How to cite this article:
Abdel Raheem MM, Mohamed WA. Impact of congenital heart disease on brain development in newborn infants.Ann Pediatr Card 2012;5:21-26


How to cite this URL:
Abdel Raheem MM, Mohamed WA. Impact of congenital heart disease on brain development in newborn infants. Ann Pediatr Card [serial online] 2012 [cited 2019 Sep 21 ];5:21-26
Available from: http://www.annalspc.com/article.asp?issn=0974-2069;year=2012;volume=5;issue=1;spage=21;epage=26;aulast=Abdel;type=0