Year : 2012  |  Volume : 5  |  Issue : 2  |  Page : 160--164

Endothelial dysfunction and atherosclerosis in children with irreversible pulmonary hypertension due to congenital heart disease


Murat Ciftel, Ayse Simsek, Özlem Turan, Firat Kardelen, Gayaz Akçurin, Halil Ertug 
 Department of Pediatric Cardiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey

Correspondence Address:
Murat Ciftel
Department of Pediatric Cardiology, Akdeniz University School of Medicine, 07070, Arapsuyu, Antalya
Turkey

Objective: To assess endothelial dysfunction and the risk for coronary atherosclerosis in children with irreversible pulmonary hypertension due to congenital heart disease (CHD). Methods: The study included 18 cyanotic patients (the mean age was 12.28 ± 3.26 years) who developed irreversible pulmonary hypertension due to cyanotic and acyanotic CHDs, and 18 control patients (the mean age was 11.78 ± 3.00 years). Study groups were compared for flow-mediated dilatation (FMD), carotid intima media thickness (CIMT) and atherosclerotic risk factors. Results: Compared to the control group, the mean FMD was significantly reduced in the cyanotic group (5.26 ± 2.42% and 9.48 ± 2.60%, respectively; P-value < 0.001). No significant difference was observed between the groups in CIMT (0.41 ± 0.08 mm and 0.39 ± 0.06 mm, respectively; P-value = 0.299). The levels of total cholesterol, low-density lipoprotein-cholesterol and very low-density lipoprotein-cholesterol were statistically significantly lower compared tothe control group (P-value = 0.001, 0.006 and 0.014, respectively), whereas no statistically significant difference was found in the levels of high-density lipoprotein-cholesterol and triglycerides (P-value = 0.113 and 0.975, respectively). Conclusions: Systemic endothelial dysfunction in children with irreversible pulmonary hypertension due to CHD was noted but there was no increased risk for atherosclerosis.


How to cite this article:
Ciftel M, Simsek A, Turan Ö, Kardelen F, Akçurin G, Ertug H. Endothelial dysfunction and atherosclerosis in children with irreversible pulmonary hypertension due to congenital heart disease.Ann Pediatr Card 2012;5:160-164


How to cite this URL:
Ciftel M, Simsek A, Turan Ö, Kardelen F, Akçurin G, Ertug H. Endothelial dysfunction and atherosclerosis in children with irreversible pulmonary hypertension due to congenital heart disease. Ann Pediatr Card [serial online] 2012 [cited 2020 Jul 5 ];5:160-164
Available from: http://www.annalspc.com/article.asp?issn=0974-2069;year=2012;volume=5;issue=2;spage=160;epage=164;aulast=Ciftel;type=0