Year : 2016  |  Volume : 9  |  Issue : 3  |  Page : 270--272

Fetal balloon aortic valvotomy: Celebrating first birthday


Nageswara Rao Koneti1, Rajan Saileela1, Jagadeesh R Singh2,  
1 Department of Pediatric Cardiology, CARE Hospitals, Hyderabad, Telangana, India
2 Department of Radiology, Asian Institute of Gastroenterology, Hyderabad, Telangana, India

Correspondence Address:
Nageswara Rao Koneti
Department of Pediatric Cardiology, CARE Hospitals, Hyderabad, Telangana
India




How to cite this article:
Koneti NR, Saileela R, Singh JR. Fetal balloon aortic valvotomy: Celebrating first birthday.Ann Pediatr Card 2016;9:270-272


How to cite this URL:
Koneti NR, Saileela R, Singh JR. Fetal balloon aortic valvotomy: Celebrating first birthday. Ann Pediatr Card [serial online] 2016 [cited 2020 Sep 29 ];9:270-272
Available from: http://www.annalspc.com/text.asp?2016/9/3/270/189111


Full Text

Sir,

We report a timely managed case of impending hypoplastic left heart syndrome (HLHS) due to critical aortic stenosis in a fetus. Fetal echocardiogram of a 25-year-old 2nd gravida during midgestation showed severe aortic stenosis. On followup, fetal heart assessment showed redistribution of flow, namely, flow reversal in the arch, left to right flow across the foramen ovale, mitral regurgitation, ventricular dysfunction, and endocardial fibroelastosis [Figure 1]a,[Figure 1]b,[Figure 1]c,[Figure 1]d. The published data supports in-utero progression to HLHS in the presence of these features.[1] Biventricular circulation is reported to be achieved in 43% of liveborn infants if fetal aortic valvotomy is performed.[2] Informed consent was obtained for the fetal balloon aortic valvotomy. At 26 weeks of gestation, after an initial unsuccessful attempt because of unfavorable fetal position, the procedure was reattempted 1 week later involving a multidisciplinary team [Table 1]. General anesthesia was given to the mother. After obtaining an ideal fetal position, intramuscular injection of vecuronium and fentanyl was given to the fetus using a 21 G needle. Under ultrasound guidance, an 18 G Hawkins-Akins needle (Cook Medical Inc, Bloomington, Indiana, USA) was introduced through the maternal abdomen, fetal thorax, and subsequently into the left ventricle. A 0.014 Galeo extrasupport wire (Biotronik AG, Ackerstrasse, Switzerland) was passed through the aortic valve and a 3.5 mm × 10 mm Hiryu balloon (Terumo Europe NV, Leuven, Belgium) was advanced over it. The balloon was inflated twice across the valve [Figure 2]a,[Figure 2]b,[Figure 2]c,[Figure 2]d. There was transient bradycardia during the procedure that recovered with atropine injection into the fetal ventricle. Mild pericardial effusion developed following the procedure, which resolved spontaneously over the next 48 h. There were no maternal complications.{Figure 1}{Table 1}{Figure 2}

The serial ultrasound assessment showed improvement of ventricular function, aortic flow, disappearance of mitral regurgitation, and reversal of shunt across foramen ovale [Figure 3]a,[Figure 3]b,[Figure 3]c,[Figure 3]d. The left ventricle and mitral annulus showed steady growth [Figure 4]. Baby was delivered by an elective cesarian section and underwent percutaneous balloon aortic valvotomy using a 5 × 20 mm Tyshak mini balloon (NuMED, Inc, Hopkinton, New York, USA). The gradient across the aortic valve dropped from 120 to 45 mmHg following the procedure. On followup, the child had normal growth and development. In the fourth month of life, the child needed a repeat balloon valvotomy using 7 × 20 mm Tyshak mini (NuMED, Inc, Hopkinon, New York, USA) balloon because of the suboptimal result obtained during neonatal period. At present, the child is 1 year old with normal growth and developmental milestones. There is mild residual aortic stenosis without regurgitation.{Figure 3}{Figure 4}

Although the world's first fetal intervention for aortic stenosis was reported 24 years ago,[3] there have been no reports of successful fetal balloon aortic valvotomy in India until now. Many social, cultural, and financial constraints play a role apart from identifying an ideal case. The success of fetal intervention depends on appropriate case selection, timing of intervention, organizing the team, selection of appropriate hardware, and experience in handling complications and postnatal management. Follow-up data of first 100 cases of fetal aortic valvuloplasty revealed achievement of biventricular circulation in 43% of liveborn cases.[2] However, the family has to be counseled that fetal intervention is never a standalone procedure. They usually need postnatal valvuloplasty as in our case. Up to 55% of those who achieved biventricular circulation also required additional cardiac surgeries during followup, such as aortic/mitral valve replacement, Ross-Konno procedure, or endocardial fibroelastosis resection.[2]

Early detection of congenital heart defects in the fetus and timely referral to a tertiary care center may help achieve biventricular circulation, which has better survival and lesser morbidity compared to Norwood procedure.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

1Mäkikallio K, McElhinney DB, Levine JC, Marx GR, Colan SD, Marshall AC, et al. Fetal aortic valve stenosis and the evolution of hypoplastic left heart syndrome: Patient selection for fetal intervention. Circulation 2006;113:1401-5.
2Freud LR, McElhinney DB, Marshall AC, Marx GR, Friedman KG, del Nido PJ, et al. Fetal aortic valvuloplasty for evolving hypoplastic left heart syndrome-postnatal outcomes of the first 100 patients. Circulation 2014;130:638-45.
3Maxwell D, Allan L, Tynan MJ. Balloon dilatation of the aortic valve in the fetus: a report of two cases. Br Heart J 1991;65:256-8.