Year : 2019  |  Volume : 12  |  Issue : 2  |  Page : 83--89

Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes


Ismael San Mauro Martín1, Sara Sanz Rojo1, Elena Garicano Vilar1, Luis Collado Yurrita2, Javier Andrés Blumenfeld Olivares3 
1 Research Centers in Nutrition and Health, Madrid, Spain
2 Department of Medicine, Universidad Complutense de Madrid, Madrid, Spain
3 Hospital El Escorial, San Lorenzo de El Escorial, Madrid, Spain

Correspondence Address:
Dr. Ismael San Mauro Martín
Research Centers in Nutrition and Health, 43 Paseo de la Habana Street, 28036, Madrid
Spain

Background: Dyslipidemias have increased during the last decades in children. Aim: The objective of this study was to analyze the influence of different polymorphisms in plasma triglyceride levels of children following a dietary treatment with plant sterols. Design: A randomized, double-blind, crossover, controlled clinical trial was carried out in 26 children (16 women). Materials and Methods: Commercial milk, with 2.24 g sterols, was ingested daily during 3 weeks , and the same amount of skimmed milk without sterols, during the 3 week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed. Results: Apolipoprotein A5 Ser19Trp (P = 0.002), peroxisome proliferator-activated receptor-alpha L162V (P = 0.003), APOE APOE2/3/4 (P = 0.012), and APOE APOE2,3,4 (P = 0.025) show statistically significant differences between their haplotypes in plasma triglyceride levels. Other genes did not show statistically significant differences. Conclusions: Further studies are needed to establish which genotype combinations would be the most protective against hypertriglyceridemia.


How to cite this article:
San Mauro Martín I, Sanz Rojo S, Garicano Vilar E, Collado Yurrita L, Blumenfeld Olivares JA. Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes.Ann Pediatr Card 2019;12:83-89


How to cite this URL:
San Mauro Martín I, Sanz Rojo S, Garicano Vilar E, Collado Yurrita L, Blumenfeld Olivares JA. Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes. Ann Pediatr Card [serial online] 2019 [cited 2019 Jul 18 ];12:83-89
Available from: http://www.annalspc.com/article.asp?issn=0974-2069;year=2019;volume=12;issue=2;spage=83;epage=89;aulast=San;type=0