Annals of Pediatric Cardiology
About us | Current Issue | Archives | Ahead of Print | Instructions | Submission | Subscribe | Advertise | Contact | Login 


    Advanced search

    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Email Alert *
    Add to My List *
* Registration required (free)  

    Article Figures

 Article Access Statistics
    PDF Downloaded339    
    Comments [Add]    
    Cited by others 4    

Recommend this journal


IMAGE Table of Contents   
Year : 2010  |  Volume : 3  |  Issue : 1  |  Page : 90-91
Pulmonary edema following transcatheter closure of atrial septal defect

Department of Pediatric Cardiology, Amrita Institute of Medical Sciences, Kochi, Kerala, India

Click here for correspondence address and email

Date of Web Publication12-Jun-2010


Pulmonary edema after device closure of atrial septal defect (ASD) is a rare complication. We present illustrative images of a case of pulmonary edema after device closure of ASD in a 53 year old adult. Older patients undergoing ASD closure can benefit from their left atrial and left ventricular end diastolic pressures measurement before and after temporary balloon occlusion of ASD.

Keywords: Atrial septal defect, pulmonary edema, catheter closure

How to cite this article:
Singhi AK, Mahesh K, Kumar R K. Pulmonary edema following transcatheter closure of atrial septal defect. Ann Pediatr Card 2010;3:90-1

How to cite this URL:
Singhi AK, Mahesh K, Kumar R K. Pulmonary edema following transcatheter closure of atrial septal defect. Ann Pediatr Card [serial online] 2010 [cited 2022 Aug 10];3:90-1. Available from:

These images illustrate the development of pulmonary edema after catheter closure of atrial septal defect (ASD) in a 53-year-old gentleman. He presented with shortness of breath and easy fatigability since six months. He was normotensive and non-diabetic with no history of effort angina. The chest x0 -ray obtained before the procedure [Figure 1] showed cardiac enlargement with dilated central pulmonary arteries and plethoric lung fields. The two-dimensional transthoracic echocardiogram revealed moderate sized secundum ASD with a left to right shunt. The right atrium, right ventricle and pulmonary artery (PA) were dilated suggestive of a significant left to right shunt. His biventricular contractility was noted to be normal. The defect size was 20 mm as measured by transesophageal echocardiography. During cardiac catheterization, the PA pressure was 53/19 (mean 32) mmHg and right ventricular end diastolic pressure eight mmHg. Coronary angiography was normal. Pressure in the left atrium and left ventricle were not measured. He underwent closure of ASD with a 22 mm device (Lifetech Scientific Ltd., Shenzen, China). Balloon sizing of the defect was not performed and the effects of temporary balloon occlusion on the left atrial or pulmonary artery pressures not measured. The device position was satisfactory and there was no residual flow.

Eighteen hours after device closure the patient developed breathing difficulty and orthopnea. Clinical examination showed tachypnea and basal crepitation. Skiagram of chest in postero-anterior view showed features of evolving pulmonary edema [Figure 2] which established after 24 hours after device closure [Figure 3]. The patient was shifted to intensive care unit and treated with intravenous diuretics. His symptoms improved over the next two days and he was discharged. On follow-up after three months, the right ventricular systolic pressure was measured 32 mmHg by tricuspid regurgitation jet. Following this event we have started to measure the left ventricular end diastolic pressures (LVEDP) in all patients older than 40 years before closing the ASD. We also test the effects of balloon occlusion on the LVEDP and PA pressures before closing the defect.

   Discussion Top

ASD is a common form of congenital heart disease accounting for approximately 10% of all congenital cardiac defects. [1] Transcatheter closure of secundum ASD has evolved over the past three decades, and is now a standard treatment for secundum ASD. Major complications after ASD device closure are rare. Du et al.[2] reported 1.6% complication rate in a cohort of 442 patients with no report of pulmonary edema. The occurrence of pulmonary edema is reported mainly in elderly patients. Ewert et al. reported pulmonary edema in a 78-year-old male. Our patient was relatively younger (53 years) without any coronary artery disease and normal systemic pressure.

In older patients, an impaired diastolic ventricular function due to reduced ventricular compliance is observed more frequently although this is occasionally also seen in childhood. [3] Restrictive left ventricular dysfunction in elderly may be masked by the presence of an ASD. Deterioration of left ventricular diastolic function can occur with acute hemodynamic change, following interventional closure of ASD, leading to acute lung edema. [4] The only independent risk factor to identify these patients is elevated left atrial pressure, which increases significantly during balloon test occlusion, indicating underlying restrictive left ventricular dysfunction. [4]

Older patients undergoing ASD closure in the catheterization laboratory should perhaps have their left atrial, LVEDP measured before and after temporary balloon occlusion and after defect is closed with a device.

   References Top

1.Carlgren LE. The incidence of congenital heart disease in children born in Gothenburg 1941-1950. Br Heart J 1959;21:40-50.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]  
2.Du Z, Hijazi ZM, Kleinman CS, Silverman NH, Larntz K. Comparison between transcatheter and surgical closure of secundum atrial septal defect in children and adults: Results of a multicenter nonrandomized trial. J Am Coll Cardiol 2002;39:1836-44.  Back to cited text no. 2      
3.Knirsch W, Dodge-Khatami A, Valsangiacomo-Buechel E, Weiss M, Berger F. Challenges encountered during closure of atrial septal defects. Pediatr Cardiol 2005;26:147-53.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]  
4.Ewert P, Berger F, Nagdyman N, Kretschmar O, Dittrich S, Abdul-Khaliq H, et al. Masked left ventricular restriction in elderly patients with atrial septal defects: A contraindication for closure? Cathet Cardiovasc Interve 2001;52:177-80.  Back to cited text no. 4      

Correspondence Address:
R Krishna Kumar
Department of Pediatric Cardiology, Amrita Institute of Medical Sciences, AIMS Ponekkra Post Office, Kochi, Kerala - 682 041
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-2069.64359

Rights and Permissions


  [Figure 1], [Figure 2], [Figure 3]

This article has been cited by
1 Challenges in Device Closure of Secundum Atrial Septal Defect in Older Patients in Their Fifth Decade and Beyond
Anil K Singhi, Soumya K Mahapatra, Dilip Kumar, Somnath Dey, Amiya Mishra, Arnab De
Cureus. 2022;
[Pubmed] | [DOI]
2 Sox18 Preserves the Pulmonary Endothelial Barrier Under Conditions of Increased Shear Stress
Christine M. Gross,Saurabh Aggarwal,Sanjiv Kumar,Jing Tian,Anita Kasa,Natalia Bogatcheva,Sanjeev A. Datar,Alexander D. Verin,Jeffrey R. Fineman,Stephen M. Black
Journal of Cellular Physiology. 2014; 229(11): 1802
[Pubmed] | [DOI]
3 Hyperacute flash pulmonary oedema after transcatheter pulmonary valve implantation: The melody of an overwhelmed left ventricle
Ganadiel Alsulami,Mehul Patel,Sophie Malekzadeh-Milani,Damien Bonnet,Younes Boudjemline
Archives of Cardiovascular Diseases. 2014;
[Pubmed] | [DOI]
4 Physiological Insights from Doppler Flow Patterns
R Krishna Kumar
Journal of Perioperative Echocardiography. 2013; 1(2): 39
[Pubmed] | [DOI]