Egmond S Evers1, Varsha Walavalkar2, Suresh Pujar2, Latha Balasubramanian2, Frits W Prinzen1, Tammo Delhaas1, Ward Y Vanagt1, Shreesha Maiya2
1 Department of Physiology and Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
2 Department of Pedicatric Cardiology, Narayana Institute of Cardiac Sciences, Bengaluru, Karnataka, India
Introduction: The early identification of vulnerable pediatric cardiac surgery patients can help clinicians provide them with timely support. Heart-type fatty acid-binding protein. (H-FABP) is an early biomarker of myocardial injury in acute myocardial infarction in adults. In this study, we evaluated the correlations between postoperative H-FABP, creatine kinase-myocardial band (CK-MB), troponin-I, total bypass time, and clinical outcomes.
Methods: In 32 pediatric patients that underwent ventricular septal defect. closure we measured H-FABP, troponin-I and CK-MB preoperatively and 1, 3, and 6 h after aortic declamping. Spearman's Rho correlations were calculated between laboratory and clinical parameters including inotropic support duration, aortic cross-clamp time, total bypass time, ventilation.weaning.time, and total Intensive Care Unit stay.
Results: H-FABP, CK-MB, troponin-I, and total bypass time have a similarly weak to moderate correlation with clinical outcome measures.
Conclusions: The predictive value of H-FABP for clinical outcome is not stronger than that of CK-MB, Troponin-I, or bypass times.
Ward Y Vanagt
Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229ER Maastricht
Source of Support: None, Conflict of Interest: None
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