Annals of Pediatric Cardiology
About us | Current Issue | Archives | Ahead of Print | Instructions | Submission | Subscribe | Advertise | Contact | Login 


    Advanced search

    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Email Alert *
    Add to My List *
* Registration required (free)  

   Case Report
    Article Figures

 Article Access Statistics
    PDF Downloaded143    
    Comments [Add]    
    Cited by others 1    

Recommend this journal


Table of Contents   
Year : 2019  |  Volume : 12  |  Issue : 2  |  Page : 138-140
Inadvertent ascending aortic perforation after transseptal puncture: Successful treatment with an Amplatzer Duct Occluder II device

Department of Paediatric Cardiology, Evelina London Children's Hospital, London, UK

Click here for correspondence address and email

Date of Web Publication30-Apr-2019


Transseptal puncture is a routine technique to access the left atrium during catheter ablation, but carries a small risk of perforation into the pericardium or aorta. When conservative management fails, surgical repair is usually needed. We report an 81-year-old male in whom aortic root perforation occurred after transseptal puncture and was treated successfully by percutaneous deployment of an Amplatzer Duct Occluder II device.

Keywords: Aortic perforation, percutaneous devices, transseptal puncture

How to cite this article:
Cao Y, Rosenthal E, Qureshi SA. Inadvertent ascending aortic perforation after transseptal puncture: Successful treatment with an Amplatzer Duct Occluder II device. Ann Pediatr Card 2019;12:138-40

How to cite this URL:
Cao Y, Rosenthal E, Qureshi SA. Inadvertent ascending aortic perforation after transseptal puncture: Successful treatment with an Amplatzer Duct Occluder II device. Ann Pediatr Card [serial online] 2019 [cited 2022 May 16];12:138-40. Available from:

   Introduction Top

Transseptal puncture is a commonly used technique to access the left atrium for diagnostic and therapeutic cardiac catheterization, including catheter ablation and valve intervention.[1] Although the risk is low, complications include atrial and aortic perforation and arterial thromboembolism.[2],[3],[4] We report an ascending aortic perforation following a transseptal puncture for catheter ablation and its subsequent successful treatment by percutaneous deployment of an Amplatzer Duct Occluder II device.

   Case Report Top

An 81-year-old male, with a history of ischemic heart disease, impaired left ventricular systolic function, and coronary artery bypass graft surgery, presented for elective ablation of slow ventricular tachycardia. After femoral venous access was obtained, an 8-French transseptal sheath and Brockenborough's needle were positioned in the fossa ovalis, and a single puncture was made under fluoroscopy followed by passage of the dilator and sheath. A test injection of contrast showed the dilator/sheath to be in the aortic root [Figure 1]a. A subsequent transesophageal echocardiogram demonstrated hematoma adjacent to the aortic root posteriorly and along the atrial walls with the dilator/sheath visualized within the aortic root.
Figure 1: Iatrogenic perforation of the aorta following transseptal puncture with 8-French sheath and dilator in the aortic root with guidewire passed through the dilator for stabilization before occlusion (a). Aortogram after percutaneous deployment of Amplatzer Duct Occluder II device (arrows, inset) and the perforation is sealed (b)

Click here to view

To avoid uncertainty with withdrawal of the dilator/sheath and conservative management, and possible need for open-heart surgery with its attendant morbidity, a decision was made to proceed with transcatheter device closure of the perforation. The transseptal sheath was passed fully into and maintained in the ascending aorta, over a 0.035” guidewire. An Amplatzer Duct Occluder II 6 mm × 4 mm (St. Jude Medical, Cardiovascular Division, St. Paul, MN, USA) was successfully deployed through the transseptal sheath with the distal disc opposed against the aortic wall, guided by transesophageal echocardiography. After an aortogram showed the device to be in a good position with no residual leak, and the echocardiogram confirmed normal aortic valve function, the device was released [Figure 1]b. Following this, a repeat transseptal puncture, guided by transesophageal echocardiography and full systemic heparinization, allowed the patient to have a successful ablation with an uneventful postprocedural recovery.

   Discussion Top

Transseptal puncture is generally considered a low-risk technique and is commonly used for accessing the left atrium during interventional and electrophysiological procedures. One early series of 1279 transseptal punctures for direct left atrial or left ventricular pressure measurements in patients with aortic or mitral valve disease, or for percutaneous aortic or mitral valvuloplasty, reported complication rates of approximately 1%, including aortic and atrial perforations leading to cardiac tamponade, and systemic arterial embolism, with one death.[4] Similarly, a large, single-center study of 450 cases revealed three aortic perforations, which were either asymptomatic or self-limiting after pericardiocentesis.[2] More recent studies have also reported slightly lower complication rates, with one multicenter study of 5520 arrhythmia ablation patients, reporting only three cases of aortic and six cases of cardiac perforation, as well as four cases of arterial thromboembolism.[3] This study also reported needle puncture of the aortic root in two cases and the right atrium in 13 cases. However, provided that the puncture is recognized early and that the dilator and sheath are not advanced further into the pericardium or the aorta, adverse outcomes associated with needle punctures are rare.[4] In this case, the initial transseptal puncture was attempted without transesophageal echocardiographic guidance. Unfortunately, by the time the ascending aortic perforation was recognized, the dilator and sheath had already been pushed into the aorta. Subsequently, transesophageal echocardiography was used for guiding the transesophageal puncture. Because of some contrast extravasation in the area of the perforation, the echocardiographic images were less than optimal quality, but sufficient to help guide the transseptal puncture.

If perforation of a cardiac structure occurs, it will usually be self-limiting after pericardiocentesis in most cases, if only the needle has been advanced.[5] However, for larger perforations caused by passing the dilator/sheath assembly that continue to bleed, the mainstay of treatment has been surgical exploration and direct suturing of the perforation.[6] Transcatheter glues such as fibrin[7] or cyanoacrylate[8] have also been tried as an alternative to open surgery. More recently, percutaneous devices, used to close atrial and ventricular septal defects, are under investigation for their utility in such complications. The possible advantages of this technique include relatively easy device deployment, provided that the perforating catheter has remained in situ, as well as avoidance of surgery in those who are not considered fit for it. Webber et al. reported a case of aortic perforation following transseptal puncture and its subsequent successful closure with an atrial septal defect closure device.[9] Mijangos-Vázquez et al. also reported on a similar complication, which was dealt with by Amplatzer Duct Occluder I.[10] However, we used an Amplatzer Duct Occluder II device, which is a softer device, to avoid any potential interference with the aortic valve cusps. As the 8-Fr sheath (effectively at least 3-mm diameter perforation) that was passed into the aorta, to avoid ongoing residual leak, we selected a 6-mm diameter device. Because of the distance between the aorta and the right atrium, we felt that a double-disc device had some advantages in providing stability of the device and rapid hemostasis of the perforation. Other double-disc devices, such as those used to close atrial and ventricular septal defects, could have been used too. We felt that the Amplatzer Duct Occluder II had similar characteristics and would seal the perforation. The patient was then proceeded to a successful ablation procedure under full systemic heparinization and had an uneventful postprocedural recovery. Due to very limited experience with these devices for cardiac perforations, complications remain largely unknown but are likely to be rare.[10]

   Conclusion Top

Aortic perforation is a potential complication of transseptal puncture. To avoid surgical repair and its attendant risks, percutaneous closure devices can be considered as an acceptable alternative for repair.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Ross J Jr., Braunwald E, Morrow AG. Transseptal left atrial puncture; new technique for the measurement of left atrial pressure in man. Am J Cardiol 1959;3:653-5.  Back to cited text no. 1
Brockenbrough EC, Braunwald E, Ross J Jr. Transseptal left heart catheterization. A review of 450 studies and description of an improved technic. Circulation 1962;25:15-21.  Back to cited text no. 2
De Ponti R, Cappato R, Curnis A, Della Bella P, Padeletti L, Raviele A, et al. Trans-septal catheterization in the electrophysiology laboratory: Data from a multicenter survey spanning 12 years. J Am Coll Cardiol 2006;47:1037-42.  Back to cited text no. 3
Roelke M, Smith AJ, Palacios IF. The technique and safety of transseptal left heart catheterization: The Massachusetts general hospital experience with 1,279 procedures. Cathet Cardiovasc Diagn 1994;32:332-9.  Back to cited text no. 4
Tsang TS, Freeman WK, Barnes ME, Reeder GS, Packer DL, Seward JB, et al. Rescue echocardiographically guided pericardiocentesis for cardiac perforation complicating catheter-based procedures. The mayo clinic experience. J Am Coll Cardiol 1998;32:1345-50.  Back to cited text no. 5
Stolt V, Cook S, Räber L, Wani S, Garachamani A, Vogel R, et al. Amplatzer septal occluder to treat iatrogenic cardiac perforations. Catheter Cardiovasc Interv 2012;79:263-70.  Back to cited text no. 6
Joho S, Asanoi H, Sakabe M, Nakagawa K, Kameyama T, Hirai T, et al. Long-term usefulness of percutaneous intrapericardial fibrin-glue fixation therapy for oozing type of left ventricular free wall rupture: A case report. Circ J 2002;66:705-6.  Back to cited text no. 7
Trehan V, Mukhopadhyay S, Yaduvanshi A, Mehta V, Roy TN, Nigam A, et al. Novel non-surgical method of managing cardiac perforation during percutaneous transvenous mitral commissurotomy. Indian Heart J 2004;56:328-32.  Back to cited text no. 8
Webber MR, Stiles MK, Pasupati S. Percutaneous repair of aortic puncture with Amplatzer closure device during attempted transseptal puncture. J Invasive Cardiol 2013;25:E110-3.  Back to cited text no. 9
Mijangos-Vázquez R, García-Montes JA, Zabal-Cerdeira C. Aortic iatrogenic perforation during transseptal puncture and successful occlusion with amplatzer ductal occluder in a case of mitral paravalvular leak closure. Catheter Cardiovasc Interv 2016;88:312-5.  Back to cited text no. 10

Correspondence Address:
Prof. Shakeel A Qureshi
Evelina London Children's Hospital, Westminster Bridge Road, London, SE1 7EH
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/apc.APC_153_18

Rights and Permissions


  [Figure 1]

This article has been cited by
1 Transseptal puncture: Review of anatomy, techniques, complications and challenges, a critical view
Marcel Almendarez, Rut Alvarez-Velasco, Isaac Pascual, Alberto Alperi, Cesar Moris, Pablo Avanzas
International Journal of Cardiology. 2022;
[Pubmed] | [DOI]