Annals of Pediatric Cardiology
About us | Current Issue | Archives | Ahead of Print | Instructions | Submission | Subscribe | Advertise | Contact | Login 


    Advanced search

    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Email Alert *
    Add to My List *
* Registration required (free)  

    Materials and Me...
    Article Figures
    Article Tables

 Article Access Statistics
    PDF Downloaded161    
    Comments [Add]    

Recommend this journal


Table of Contents   
Year : 2021  |  Volume : 14  |  Issue : 3  |  Page : 323-330
Concomitant pulmonary valve replacement with intracardiac repair for adult tetralogy of fallot

1 Department of Cardio Vascular and Thoracic Surgery, U.N. Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India
2 Department of Pediatric Cardiac Surgery, U.N. Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India
3 Department of Research, U.N. Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India

Click here for correspondence address and email

Date of Submission27-May-2020
Date of Decision18-Sep-2020
Date of Acceptance27-May-2021
Date of Web Publication12-Aug-2021


Objectives : Adult patients undergoing tetralogy of Fallot (TOF) repair have a higher risk of mortality compared to pediatric patients. Pulmonary regurgitation (PR) further predisposes these patients to heart failure, arrhythmias, and sudden death. Pulmonary valve replacement (PVR) may improve the symptoms in these patients but, fails to reverse the other deleterious effects. Aim of our study was to evaluate the effect of concomitant PVR with TOF repair on right ventricular (RV) parameters, cardiopulmonary exercise capacity, and bioprosthetic valve durability at mid-term.
Materials and Methods: Between January 2013 and August 2018, 37 adolescents and adults with TOF who had hypoplastic pulmonary annulus underwent concomitant TOF repair with PVR at our institute. We retrospectively collected the data from the hospital records including follow-up.
Results : Mean age of the patients was 18.48 ± 7.53 years. Bioprosthetic valve size ranged from 19 mm to 25 mm. There was no early or late mortality. No patient had developed significant perioperative complications. At a mean follow-up of 53.3 ± 16.4 months, there was no significant change in mean QRS duration, RV function, RV end-systolic and end-diastolic dimensions, RV myocardial performance index, and functional status (including NYHA class and 6-min walk test) compared to at-discharge values. Four patients developed prosthetic valve degeneration with mild PR and without significant increase in gradient.
Conclusion : Concomitant PVR with TOF repair in adult provides excellent mid-term outcome, with a minimal rate of pulmonary valve degeneration. It not only eases the early postoperative course but also preserves the RV function as well as functional status at mid-term.

Keywords: Bioprosthetic valve, pulmonary valve, tetralogy of fallot

How to cite this article:
Jain A, Rajan SK, Patel K, Garg P, Agrawal V, Kakkar D, Gajjar T, Mishra A, Patel S, Doshi C. Concomitant pulmonary valve replacement with intracardiac repair for adult tetralogy of fallot. Ann Pediatr Card 2021;14:323-30

How to cite this URL:
Jain A, Rajan SK, Patel K, Garg P, Agrawal V, Kakkar D, Gajjar T, Mishra A, Patel S, Doshi C. Concomitant pulmonary valve replacement with intracardiac repair for adult tetralogy of fallot. Ann Pediatr Card [serial online] 2021 [cited 2022 Aug 15];14:323-30. Available from:

   Introduction Top

Pulmonary regurgitation (PR) is an unfortunate consequence of trans-annular patch (TAP) in patients undergoing tetralogy of Fallot (TOF) repair. Longstanding PR results in right ventricular (RV) dysfunction, prolongation of QRS duration, supraventricular and ventricular arrhythmias, and reduced life expectancy.[1],[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13] Therefore, symptomatic chronic PR is an indication for pulmonary valve replacement (PVR). However, studies have shown that even after PVR, there is no significant improvement in the uncorrected RV ejection fraction (UnRVEF) and the corrected RVEF also improves only to the extent of preoperative UnRVEF. Both these facts reiterate that PVR does not improve RV dysfunction.[8],[9],[10] Further, PVR late after the onset of PR may partially or completely fail to normalize RV end-diastolic volume and end-systolic volume (ESV), QRS duration, and exercise capacity.[4],[7] Further, PVR also fails to reduce the incidence of ventricular tachycardia (VT) or sudden death once the QRS duration is >180 ms.[7],[12] Hence, Jost et al. have advocated concomitant PVR in adult patients with TOF who have hypoplastic pulmonary annulus (HPA).[1] However, data are still limited about the outcome of concomitant PVR with TOF repair in adolescent and adult patients. The aim of our retrospective study was to evaluate the effect of concomitant PVR on RV parameters, cardiopulmonary exercise capacity, and bioprosthetic valve durability at mid-term.

   Materials and Methods Top

The study protocol was approved by the Ethics Committee of our institute and patient's consent was waived off in view of the retrospective nature of the study. Between January 2013 and August 2018, 37 adolescents and adults with TOF and HPA underwent concomitant TOF repair with PVR at our institute. We retrospectively collected perioperative and follow-up data from the hospital records. Perioperatives data included symptoms and previous palliation; electrocardiography (ECG) for rhythm, arrhythmias, and QRS duration; echocardiography; computed tomography pulmonary angiography (CTPA) and cardiac catheterization for major aortopulmonary collaterals (MAPCAs) and their management; operative procedure-type and size of bioprosthesis, postrepair right ventricle to left ventricle pressure ratio (pRV/LV); inotropic score, duration of mechanical ventilation, intensive care unit (ICU), and hospital stay, and postoperative mortality.

Surgical technique

All patients were operated under moderate hypothermic (28°C–32°C) blood cardioplegic arrest through midline sternotomy. The approach used was through the right atrium-right ventricle. Significant MAPCAs amenable to occlusion with coil were occluded day before surgery. MAPCAs not amenable for coil occlusion and/or patent palliative shunts were ligated immediately after the commencement of cardiopulmonary bypass. Right ventriculotomy was extended across the pulmonary annulus. After the resection of hypertrophied infundibular muscle bundles and patch closure of the ventricular septal defect, aortic bioprosthesis was sutured at pulmonary annulus facing downward using 5-0 prolene continuous sutures. The residual defect anteriorly was repaired with fixed autologous pericardium suturing the rest of the valve to the pericardium, anteriorly. Postrepair, anterior surface of the heart and great vessels were covered with pericardial membrane (0.1 mm enhanced-polytetrafluoroethylene (Gore-Tex™) patch) to facilitate safe sternotomy during inevitable future re-operations.

All patients were continued on oral warfarin for 3 months postoperatively and international normalized ratio was maintained between 2 and 3.

Follow-up data

Follow-up data were collected till December 2018. Follow-up data included clinical symptoms, ECG, and echocardiography. We also collected the data for 6 min walk test at discharge and during follow-up.

Echocardiography data for LV included ejection fraction (LVEF). For RV included pulmonary valve (PV) mean (Gmean) and maximum (Gmax) gradient, systolic pressure (RVSP), end-diastolic area (RVEDA), end-systolic area (RVESA), myocardial perfusion index (RVMPI) (TEI index), fractional area change (RVFAC), tricuspid annular plane systolic excursion (TAPSE), and any residual surgical lesion. RV outflow tract obstruction (RVOTO) was graded according to the American Society of Echocardiography guidelines for pulmonic stenosis (PS).[14]

Statistical analysis

Statistical analyses were performed with the SPSS 22.0 software (SPSS, Inc., Chicago, IL, USA). Continuous variables are expressed as mean with standard deviations. Categorical data are expressed as percentages. Continuous variables in the immediate postoperative period and last follow-up were compared using Students paired t-test. P <0.05 was considered significant.

   Results Top

The demographic profile of the patients is shown in [Table 1]. The mean age of the patients was 18.48 ± 7.53 years and there were 16 males and 21 females. All patients were in sinus rhythm with mean QRS duration of 92 ± 6.5 ms. Four patients had been palliated previously with modified Blalock Taussig shunt and shunt was patent in three patients (blocked in one patient). A total of 10 patients had significant MAPCAs on preoperative CTPA. Total 12 MAPCAs were coil occluded in five patients, preoperatively. Preoperative TAPSE was 1.89 ± 0.3 cm.
Table 1: Demographic, clinical and echocardiographic variables of tetralogy of fallot repair with pulmonary valve replacement patients

Click here to view

Operative data are shown in [Table 2]. The bioprosthetic valve was used for PVR in all the patients and size ranged from 19 mm to 25 mm. 19 mm valve was used in three patients with BSA of 0.6, 0.67, and 0.7 mm/m2. Total 8 MAPCAs in five patients (13.5%) were ligated surgically at the time of TOF repair. Postoperative pRV/LV ratio was 0.55 ± 0.10 (range 0.3–0.7) and RV to PA gradient was 13.3 ± 5.7 mmHg. There was no PR in any patient.
Table 2: Operative characteristics of tetralogy of fallot repair with pulmonary valve replacement patients

Click here to view

Postoperative data are shown in [Table 3]. The mean vasopressor inotropic score was 13.16 ± 3.32. The mean duration of mechanical ventilation was 10.37 ± 6.2 h and ICU stay was 3.5 ± 0.9 days. There was no operative mortality. No patient had developed low cardiac output syndrome (LCOS), acute renal failure (ARF), ventricular dysfunction, arrhythmias, or sepsis. Postrepair, mean central venous pressure (CVP) was 7 ± 2.1 mmHg, and mean RV end-diastolic pressure (RVEDP) was 8.5 ± 3.4 mmHg. Two patients developed pleural effusion that required drainage and two patients required re-intubation. At discharge, all patients were in sinus rhythm, and the mean QRS duration was 103 ± 6.7 ms. In echocardiography, mean RVEDA and mean RVESA were 13.7 ± 1.2 cm2 and 8.53 ± 1.13 cm2, respectively. RVMPI was 0.30 ± 0.07. Mean RVFAC was 43.7 ± 5.21% and mean TAPSE was 1.79 ± 0.21 cm. There was no significant difference between preop and early postoperative TAPSE (P = 0.1010). The mean RVSP, maximum and mean gradient across the PV were 36.78 ± 8 mmHg, 23.58 ± 7.3 mmHg, and 10 ± 2.8 mmHg, respectively. Mean LVEF was 62.1 ± 4.2% and there was no significant residual lesion or valve regurgitation. The 6 min walk distance was 507.49 ± 36.7 m.
Table 3: Postoperative and follow-up parameters in tetralogy of fallot repair with pulmonary valve replacement patients

Click here to view


Functional status and electrocardiographic changes

Follow-up was 100% complete and the mean duration of follow-up was 53.3 ± 16.4 months. There was no mortality and no patient required reoperation or re-interventions during follow-up. At the last follow-up, 35 patients (94.6%) were NYHA Class I, and two patients (5.4%) were NYHA Class II [Table 4]. All the patients were in sinus rhythm without any atrial or ventricular ectopic and were leading an active life. The mean QRS duration was 106 ± 7.2 ms. Six-minute walk distance at the last follow-up was 506.67 ± 40.7 m.
Table 4: Change in functional class at discharge and during follow.up in tetralogy of fallot repair with pulmonary valve replacement patients

Click here to view

Compared to preoperative status, there, there was a significant improvement in the NYHA class (P < 0.001) [Table 4]. In ECG, mean QRS duration increased significantly early after surgery and remained increased during follow-up (P < 0.0001). However, compared to QRS duration at discharge, it did not change significantly during follow-up (103 ± 6.7 vs. 106 ± 7.2; P = 0.067) [Figure 1]. Six-minute walk distance did not change significantly during follow-up (P = 0.64).
Figure 1: Change in QRS duration in the study population at discharge and during follow-up

Click here to view

Echocardiography parameters during follow-up

At the last follow-up, the mean LVEF was 65.1 ± 6.0%. Mean RVEDA and mean RVESA were 14.1 ± 0.9 cm2 and 8.78 ± 1.22 cm2, respectively. RVMPI was 0.31 ± 0.09. Mean RVFAC was 45.3 ± 4.52% and mean TAPSE was 1.84 ± 0.26 cm. None of these parameters changed significantly during follow-up [Table 5]. The mean RVSP, maximum and mean gradient across the PV were 39.73 ± 8.5 mmHg, 26.58 ± 7.3 mmHg, and 11 ± 3.8 mmHg, respectively. There was no significant increase in any of these parameters. Two patients (5.4%) developed moderate PR and two patients (5.4%) developed moderate PS during follow-up. No patient had any significant residual shunt or valve regurgitation.
Table 5: Comparison of echocardiography parameters early after surgery and during follow-up in tetralogy of fallot repair with pulmonary valve replacement patients

Click here to view

On comparing the patients aged <17 years (n = 15) and >17 years (n = 22) at the time of surgery, incidence of bioprosthetic valve dysfunction was more in patients aged <17 years (20%) compared to patients aged ≥17 years (4.5%). However, the difference was not statistically significant. (P = 0.13)

   Discussion Top

Numerous studies in the last 40 years have reiterated that TOF repair with competent PV not only results in the smooth perioperative course but also better long-term outcome in terms of ventricular function, symptoms, and survival.[15],[16],[17] Our results also reaffirm that TOF repair with concomitant PVR can be safely performed in adolescent and adult patients without mortality and good outcome at midterm without significant valvular degeneration. All our patients remained clinically asymptomatic with preserved exercise capacity, RV contractility, and dimensions at mid-term.

Why concomitant pulmonary valve replacement in adolescent and adult patients with tetralogy of Fallot?

After the insertion of TAP, RVOT becomes akinetic or dyskinetic along with variable severity of PR. This results in reduced effective forward flow, increased RVESV and the development of subclinical RV diastolic dysfunction long before the patients become symptomatic.[18] Gradually, patients develop symptoms of congestive heart failure with reduced exercise capacity, ventricular and supraventricular arrhythmias, and increased risk of sudden cardiac death.[19] PVR in these patients after the development of complications results in only limited improvement in their ventricular function, QRS duration, and clinical symptoms.[10] Studies have also found that PVR done more than 2 years after the TAP may fail to reverse RV dysfunction and exercise performance to normal.[20] These observations highlight the importance of achieving a competent PV at the initial TOF repair in adults. We believe that PVR not only establishes the competency of PV but, also creates a neo-pulmonary annulus mitigating the RVOT patch-related dysfunction.

Early and mid-term outcome of tetralogy of Fallot repair with pulmonary valve replacement in adult patients

Perioperative morbidity and mortality

In our study, no patient developed LCOS, arrhythmias, ARF or ventricular dysfunction. Vasopressor inotropic score was low and 80% of patients were extubated within 12 h of surgery. Postrepair, mean CVP was 7 ± 2.1 mmHg and mean RVEDP was 8.5 ± 3.4 mmHg suggesting the absence of RV dysfunction despite the presence of severe RV hypertrophy. The incidence of pleural effusion and re-intubation was 5.4% which is comparable to other studies.[1],[17] Operative mortality for TOF repair in adults is higher (4%–8%) compared to pediatric patients (<1%).[1] Studies have cited previous palliation and older age at repair (>40 years) as important risk factors for perioperative mortality.[1] In our series, there was no operative mortality. We believe that relatively younger age (mean 18.48 years) of our patients and low incidence of previous palliation (11%) were the major contributory factor for zero mortality in our series. We are not sure whether the protective effect of competent pulmonary valve on RV function had any role in good outcome in our series.

Functional improvement

The myocardium in adult patients with TOF is usually jeopardized due to prolonged hypoxia, polycythemia and severe hypertrophy. Any amount of PR, pulmonary stenosis or other residual lesions further worsen their ventricular function.[1],[18],[19],[20] Complete repair without residual lesion and competent PV can circumvent many deleterious effects on already compromised myocardium and improve the functional outcome. In our study, functional outcome was excellent with all the patients in NYHA Class I or II at follow-up of 53.3 ± 16.4 months. We attribute our excellent results to the younger age of the patients and the absence of PR or residual lesions. Similar results are reported by Patel et al.[17] and Waien et al.[21] In the prospective observational study by Patel et al., 235 patients with TOF who underwent trans-right atrial repair and had minimal or mild PR in the postoperative period; patients had near-normal VO2 max at mean follow-up of 6.10 ± 1.86 years.

Arrhythmias, sudden death and long-term survival

Patients operated for TOF are at increased risk of arrhythmias and sudden death. Although, atrial fibrillation is the most frequent arrhythmia; ventricular tachycardia (VT) is the most common cause of sudden death and is attributed to the prolongation of QRS duration. QRS duration >180 ms predisposes the patient to the risk of VT and once a patient develops VT, PVR does not reduce the incidence of sudden death.[1],[7],[12],[22]Apart from QRS duration, reduction in LVEF is also an important risk factor for survival after PVR. In a study done by Tobler et al., they found that QRS duration >180 ms combined with the reduction in LVEF had the highest positive predictive value for sudden cardiac death.[23] These findings are further substantiated by the meta-analysis done by Ferraz Cavalcant et al. The authors concluded in their meta-analysis that reduction of QRS duration and improvement in LVEF after PVR in combination might mean reduction in long-term mortality.[10] Therefore, PVR should be done after TOF repair sooner than later before the patient develops the irreversible changes in QRS duration and LVEF. A study by Harrild et al. found that after PVR, QRS duration tends to stabilize only when pre-PVR QRS duration <150 ms while, it continues to progress if pre-PVR QRS duration >160 ms.[12] All these observations substantiate that any duration of PR has deleterious effect on the myocardium. Therefore, we believe that whenever possible, primary prevention of PR is better than its treatment at a later stage to mitigate the long-term complications. Our results confirm the same. At mid-term follow-up, all our patients remained in sinus rhythm with mean QRS duration of 106 ± 7.2 ms and there was no evidence of atrial or ventricular arrhythmia in ECG. We, however, did not perform Holter monitoring in any patient to confirm the same.

Only 24%–73% of patients who undergo TOF repair in adulthood survive for 10 years.[1] In our series, survival was 100% at mid-term. We believe that it is due to the younger age of our patients, preserved ventricular function, and shorter duration of follow-up. We need a longer duration of follow-up to determine whether concomitant TOF repair and PVR results in improved long-term survival considering that all our patients are at risk for bioprosthetic valve degeneration and may require repeated surgeries for PV in future.[1],[24]

Choice of pulmonary prosthesis

The bioprosthetic valve is the prosthesis of choice at the pulmonary position. It has many advantages (1) It is easy to implant, functions reliably, and does not require prolonged systemic anticoagulation. (2) Maintains the continuity between RV and branch pulmonary arteries by native tissue hence less risk of calcification. (3) Ease of percutaneous valve-in-valve implantation. (4) Ease of percutaneous intervention for the pulmonary arterial tree. (5) Prosthesis of choice in patients with significant RV dysfunction or congestive heart failure.

Although, recent study with the limited number of patients has shown comparable results with mechanical prosthesis at the pulmonary position with acceptable thrombotic and hemorrhagic complications;[25] still, mechanical prosthesis at pulmonary position requires robust systemic anticoagulation and it is reserved for the patients who have mechanical prosthesis at any other position or have any associated condition warranting anticoagulation.

Bioprosthetic valve degeneration

In our institute, we prefer stented bioprosthesis for PVR. Studies have uniformly reported better long-term durability of the stented bioprosthetic valve over homograft or Dacron porcine-valved conduit.[26] However, amongst stented bioprosthetic valves, studies have consistently failed to establish the superiority of the pericardial valve over the porcine valve or vice versa in terms of valve degeneration and improved survival.[27],[28] In this study, at the mean follow-up of 53.3 ± 16.4 months, 4(10.8%) patients developed bioprosthetic valve degeneration. However, we did not compare the different valve types due to the limited number of patients.

Regarding bioprosthetic valve degeneration based on age, our results are in congruence with previous studies.[28],[29] Similar to the previous study, we also found that valve degeneration was more frequent in younger patients (20% v/s. 4.5% in patients aged <17 years and ≥17 years, respectively). The difference, however, did not reach the statistically significant level due to the limited number of patients and shorter duration of follow-up.

Limitations of the study

Our study has many limitations. First, ours is retrospective study with a small sample size. Second, there is no control arm of adult patients with TAP to compare the difference in the result. Third, we have not used cardiac magnetic resonance imaging which is a better modality to assess RV size and function. Fourth, we had not performed 24-h Holter monitoring to record subclinical arrhythmias. Fifth, short duration of follow-up. Therefore, we recommend studies involving a larger number of patients in both the arms and longer duration of follow-up.

   Conclusion Top

In adult patients with TOF and HPA, concomitant PVR with TOF repair can be safely performed without the increased risk of mortality, acceptable rate of PV degeneration, and excellent outcome at mid-term. PVR not only eases the perioperative course but, preserves the ventricular function as well as functional status of the patient during follow-up.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Attenhofer Jost CH, Connolly HM, Burkhart HM, Scott CG, Dearani JA, Carroll AJ, et al. Tetralogy of Fallot repair in patients 40 years or older. Mayo Clin Proc 2010;85:1090-4.  Back to cited text no. 1
Babu-Narayan SV, Diller GP, Gheta RR, Bastin AJ, Karonis T, Li W, et al. Clinical outcomes of surgical pulmonary valve replacement after repair of ToF and potential prognostic value of preoperative cardiopulmonary exercise testing. Circulation 2014;129:18-27.  Back to cited text no. 2
Geva T. Repaired tetralogy of Fallot: The roles of cardiovascular magnetic resonance in evaluating pathophysiology and for pulmonary valve replacement decision support. J Cardiovasc Magn Reson 2011;13:9.  Back to cited text no. 3
Therrien J, Provost Y, Merchant N, Williams W, Colman J, Webb G. Optimal timing for pulmonary valve replacement in adults after tetralogy of Fallot repair. Am J Cardiol 2005;95:779-82.  Back to cited text no. 4
Gatzoulis MA, Balaji S, Webber SA, Siu SC, Hokanson JS, Poile C, et al. Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: A multicentre study. Lancet 2000;356:975-81.  Back to cited text no. 5
Khairy P, Aboulhosn J, Gurvitz MZ, Opotowsky AR, Mongeon FP, Kay J, et al. Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: A multi-institutional study. Circulation 2010;122:868-75.  Back to cited text no. 6
Oosterhof T, Vliegen HW, Meijboom FJ, Zwinderman AH, Bouma B, Mulder BJ. Long-term effect of pulmonary valve replacement on QRS duration in patients with corrected tetralogy of Fallot. Heart 2007;93:506-9.  Back to cited text no. 7
Hsu C, Puranik R. Pulmonary valve replacement in adults with repaired tetralogy of Fallot: The role of cardiac magnetic resonance beyond volume measurements. Future Cardiol 2012;8:801-4.  Back to cited text no. 8
Heng EL, Gatzoulis MA, Uebing A, Sethia B, Uemura H, Smith GC, et al. Immediate and midterm cardiac remodeling after surgical pulmonary valve replacement in adults with repaired tetralogy of Fallot: A prospective cardiovascular magnetic resonance and clinical study. Circulation 2017;136:1703-13.  Back to cited text no. 9
Ferraz Cavalcanti PE, Sá MP, Santos CA, Esmeraldo IM, de Escobar RR, de Menezes AM, et al. Pulmonary valve replacement after operative repair of tetralogy of Fallot: Meta-analysis and meta-regression of 3,118 patients from 48 studies. J Am Coll Cardiol 2013;62:2227-43.  Back to cited text no. 10
He F, Feng Z, Chen Q, Jiao Y, Hua Z, Zhang H, et al. Whether pulmonary valve replacement in asymptomatic patients with moderate or severe regurgitation after tetralogy of Fallot repair is appropriate: A case-control study. J Am Heart Assoc 2019;8:e010689.  Back to cited text no. 11
Harrild DM, Berul CI, Cecchin F, Geva T, Gauvreau K, Pigula F, et al. Pulmonary valve replacement in tetralogy of Fallot: Impact on survival and ventricular tachycardia. Circulation 2009;119:445-51.  Back to cited text no. 12
Lim C, Lee JY, Kim WH, Kim SC, Song JY, Kim SJ, et al. Early replacement of pulmonary valve after repair of tetralogy: Is it really beneficial? Eur J Cardiothorac Surg 2004;25:728-34.  Back to cited text no. 13
Hahn RT, Abraham T, Adams MS, Bruce CJ, Glas KE, Lang RM, et al. Guidelines for performing a comprehensive transesophageal echocardio-graphic examination in children and all patients with congenital heart disease: Recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr 2018;32:173-215.  Back to cited text no. 14
Brown JW, Ruzmetov M, Vijay P, Rodefeld MD, Turrentine MW. Right ventricular outflow tract reconstruction with a polytetrafluoroethylene monocusp valve: A twelve-year experience. J Thorac Cardiovasc Surg 2007;133:1336-43.  Back to cited text no. 15
Boni L, García E, Galletti L, Pérez A, Herrera D, Ramos V, et al. Current strategies in tetralogy of Fallot repair: Pulmonary valve sparing and evolution of right ventricle/left ventricle pressures ratio. Eur J Cardiothorac Surg 2009;35:885-9.  Back to cited text no. 16
Patel K, Talwar S, Gupta SK, Choudhary SK, Kothari SS, Airan B. Transatrial repair of tetralogy of Fallot: Midterm results. Indian J Thorac Cardiovasc Surg 2015;31:1-7.  Back to cited text no. 17
Nair KK, Ganapathi S, Sasidharan B, Thajudeen A, Pillai HS, Tharakan J, et al. Asymptomatic right ventricular dysfunction in surgically repaired adult tetralogy of Fallot patients. Ann Pediatr Cardiol 2013;6:24-8.  Back to cited text no. 18
Davlouros PA, Kilner PJ, Hornung TS, Li W, Francis JM, Moon JC, et al. Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: Detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction. J Am Coll Cardiol 2002;40:2044-52.  Back to cited text no. 19
Ilbawi MN, Idriss FS, DeLeon SY, Muster AJ, Gidding SS, Berry TE, et al. Factors that exaggerate the deleterious effects of pulmonary insufficiency on the right ventricle after tetralogy repair. Surgical implications. J Thorac Cardiovasc Surg 1987;93:36-44.  Back to cited text no. 20
Waien SA, Liu PP, Ross BL, Williams WG, Webb GD, McLaughlin PR. Serial follow-up of adults with repaired tetralogy of Fallot. J Am Coll Cardiol 1992;20:295-300.  Back to cited text no. 21
Scherptong RW, Hazekamp MG, Mulder BJ, Wijers O, Swenne CA, van der Wall EE et al. Follow-up after pulmonary valve replacement in adults with tetralogy of Fallot: association between QRS duration and outcome. J Am Coll Cardiol 2010;56:1486–92.  Back to cited text no. 22
Tobler D, Crean AM, Redington AN, Van Arsdell GS, Caldarone CA, Nanthakumar K, et al. The left heart after pulmonary valve replacement in adults late after tetralogy of Fallot repair. Int J Cardiol 2012;160:165-70.  Back to cited text no. 23
Discigil B, Dearani JA, Puga FJ, Schaff HV, Hagler DJ, Warnes CA, et al. Late pulmonary valve replacement after repair of tetralogy of Fallot. J Thorac Cardiovasc Surg 2001;121:344-51.  Back to cited text no. 24
Stulak JM, Connolly HM, Puga FJ, Dearani JA, Warnes CA, Schaff HV. Should mechanical valves be used in the pulmonary position? J Am Coll Cardiol 2004;43 5 Suppl 2:A390-1.  Back to cited text no. 25
Lee C, Park CS, Lee CH, Kwak JG, Kim SJ, Shim WS, et al. Durability of bioprosthetic valves in the pulmonary position: Long-term follow-up of 181 implants in patients with congenital heart disease. J Thorac Cardiovasc Surg 2011;142:351-8.  Back to cited text no. 26
Kwak JG, Lee C, Lee M, Lee CH, Jang SI, Lee SY, et al. Does implantation of larger bioprosthetic pulmonary valves in young patients guarantee durability in adults? Durability analysis of stented bioprosthetic valves in the pulmonary position in patients with Tetralogy of Fallot. Eur J Cardiothorac Surg 2016;49:1207-12.  Back to cited text no. 27
Abbas JR, Hoschtitzky JA. Which is the best tissue valve used in the pulmonary position, late after previous repair of tetralogy of Fallot?. Interactive cardiovascular and thoracic surgery. 2013 Nov 1;17(5):854-60.  Back to cited text no. 28
Zubairi R, Malik S, Jaquiss RD, Imamura M, Gossett J, Morrow WR. Risk factors for prosthesis failure in pulmonary valve replacement. Ann Thorac Surg 2011;91:561-5.  Back to cited text no. 29

Correspondence Address:
Dr. Kartik Patel
Department of Cardio Vascular and Thoracic Surgery, U. N. Mehta Institute of Cardiology and Research Center, Civil Hospital Campus, Asarwa, Ahmedabad - 380 016, Gujarat
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/apc.APC_125_20

Rights and Permissions


  [Figure 1]

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]