Year : 2014  |  Volume : 7  |  Issue : 2  |  Page : 107--117

Familial hypercholesterolemia: A review

Mithun J Varghese 
 Department of Cardiology, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Dr. Mithun J Varghese
Department of Cardiology, Christian Medical College, Vellore - 632 004, Tamil Nadu

Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism resulting in elevated serum low-density lipoprotein (LDL) cholesterol levels leading to increased risk for premature cardiovascular diseases (CVDs). The diagnosis of this condition is based on clinical features, family history, and elevated LDL-cholesterol levels aided more recently by genetic testing. As the atherosclerotic burden is dependent on the degree and duration of exposure to raised LDL-cholesterol levels, early diagnosis and initiation of treatment is paramount. Statins are presently the mainstay in the management of these patients, although newer drugs, LDL apheresis, and other investigational therapies may play a role in certain subsets of FH, which are challenging to treat. Together these novel treatments have notably improved the prognosis of FH, especially that of the heterozygous patients. Despite these achievements, a majority of children fail to attain targeted lipid goals owing to persistent shortcomings in diagnosis, monitoring, and treatment. This review aims to highlight the screening, diagnosis, goals of therapy, and management options in patients with FH.

How to cite this article:
Varghese MJ. Familial hypercholesterolemia: A review.Ann Pediatr Card 2014;7:107-117

How to cite this URL:
Varghese MJ. Familial hypercholesterolemia: A review. Ann Pediatr Card [serial online] 2014 [cited 2022 Oct 5 ];7:107-117
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