Year : 2020  |  Volume : 13  |  Issue : 3  |  Page : 241--243

Steroid-associated bradycardia in a newly diagnosed B precursor acute lymphoblastic leukemia patient with Holt–Oram syndrome


Raymond Morales1, Bishir Clayton2, Hoang H Nguyen1, Lisa Giordano1, Brieann A Muller1 
1 Department of Pediatrics, Rush University Medical Center, Chicago, IL, USA
2 Rush Medical College, Rush University, Chicago, IL, USA

Correspondence Address:
Raymond Morales
Department of Pediatrics, Rush University Medical Center, 1653 W Congress Parkway, Pavilion 654, Chicago 60612, IL
USA

Holt–Oram syndrome (HOS) (OMIM#142900) is a rare condition with upper extremity malformations as well as structural and conduction cardiac anomalies. There are sparse reports in the literature documenting malignancy in association with HOS. We report a pediatric patient clinically diagnosed with HOS (missing thumbs bilaterally, atrial septal defect, ventricular septal defect, and first-degree heart block), who also developed B precursor acute lymphoblastic leukemia. During induction of chemotherapy with steroids, she developed profound bradycardia without clinical symptoms. The bradycardia resolved without intervention, but this case highlights the challenges of managing chemotherapy side effects in a patient with congenital heart disease. A literature review pertinent to the associated findings in the case is also presented.


How to cite this article:
Morales R, Clayton B, Nguyen HH, Giordano L, Muller BA. Steroid-associated bradycardia in a newly diagnosed B precursor acute lymphoblastic leukemia patient with Holt–Oram syndrome.Ann Pediatr Card 2020;13:241-243


How to cite this URL:
Morales R, Clayton B, Nguyen HH, Giordano L, Muller BA. Steroid-associated bradycardia in a newly diagnosed B precursor acute lymphoblastic leukemia patient with Holt–Oram syndrome. Ann Pediatr Card [serial online] 2020 [cited 2022 Aug 20 ];13:241-243
Available from: https://www.annalspc.com/article.asp?issn=0974-2069;year=2020;volume=13;issue=3;spage=241;epage=243;aulast=Morales;type=0