Ann Pediatr Card Close
 

Figure 2: Development of the coronary arteries. Movement of the PEO to and over the heart is shown in the top panel, and mesenchymal migration and differentiation are shown in the bottom panel. The PEO (blue) is seen as an outgrowth from the dorsal body wall that moves to the looping heart (red). Next, migrating epithelium is seen spreading over the heart. In cross section, the epithelium is seen as a single cell layer. Epithelial/mesenchymal transition provides cells that migrate into the myocardium. Vasculogenic cells differentiate and link to form plexi that induce other mesenchymal cells to become smooth muscle. These plexi are remodelled into definitive arteries, and the most proximal points of the major coronaries finally link up with the aorta[10]

Figure 2: Development of the coronary arteries. Movement of the PEO to and over the heart is shown in the top panel, and mesenchymal migration and differentiation are shown in the bottom panel. The PEO (blue) is seen as an outgrowth from the dorsal body wall that moves to the looping heart (red). Next, migrating epithelium is seen spreading over the heart. In cross section, the epithelium is seen as a single cell layer. Epithelial/mesenchymal transition provides cells that migrate into the myocardium. Vasculogenic cells differentiate and link to form plexi that induce other mesenchymal cells to become smooth muscle. These plexi are remodelled into definitive arteries, and the most proximal points of the major coronaries finally link up with the aorta<sup>[10]</sup>